RESEARCH

Early is grounded in science.

The Early program is built on a deep, biological understanding of weight management. Explore the peer-reviewed research that powers our approach to sustainable weight loss.

Our Most Impactful Studies

GLP-1 Therapies: A Review of Clinical Trials

THE JOURNAL OF ENDOCRINOLOGY AND METABOLISM

  • Semaglutide (Wegovy) resulted in significant weight loss of up to 14.9% in the landmark STEP trials.
  • Tirzepatide (Zepbound), a dual-action agent, achieved even greater weight loss of up to 26.6% in SURMOUNT trials.
  • Earlier therapies like Liraglutide (Saxenda) demonstrated weight loss of up to 8% , establishing the foundation for GLP-1 treatment.
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Tirzepatide Once Weekly for the Treatment of Obesity

THE NEW ENGLAND JOURNAL OF MEDICINE

  • Patients on the highest dose (15mg) lost an average of 20.9% of their starting body weight over 72 weeks.
  • The 10mg dose group saw an average weight loss of 19.5% , while the 5mg group lost 15.0% .
  • About half of the individuals on higher doses lost 20% or more of their body weight, a result achieved by only 3% on placebo.
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Sustained Weight Loss with Tirzepatide (3-Year Trial)

LILLY RESEARCH

  • Demonstrated remarkable and sustained weight loss, with patients losing an average of 22.9% over 3 years.
  • This represents the longest and most sustained weight loss observed in any major obesity medicine trial to date.
  • This durable weight loss was associated with a 94% reduction in the risk of progressing to type 2 diabetes.
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Tirzepatide for Weight Reduction in Asian Adults

THE SURMOUNT-CN RANDOMIZED CLINICAL TRIAL

  • Participants lost up to 17.5% of their body weight over 52 weeks, confirming strong efficacy in this population.
  • A significant 86% of individuals taking Tirzepatide lost at least 5% of their body weight.
  • The study confirmed Tirzepatide as a powerful option, showing similar effectiveness to global studies.
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*Individual results may vary. Weight loss depends on various factors including adherence to treatment, lifestyle changes, and individual health conditions. Results are not guaranteed.

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