How It Works & Its Primary Uses

Mounjaro is a once-weekly injectable medication whose active ingredient, tirzepatide, is a dual incretin agonist (stimulating both GLP-1 and GIP receptors). This mimics two gut hormones that increase insulin release, suppress excess glucagon, slow stomach emptying, and signal fullness. The combined GLP-1/GIP action makes tirzepatide especially potent: clinical trials report large HbA1c reductions (often 1–2% or more) and substantial weight loss (up to 20% or more) Mounjaro was approved in India in March 2025 for both Type 2 diabetes and obesity, making it the first dual-incretin drug available for weight loss in India. Think of it as a “smart helper” that boosts insulin and satiety hormones together to improve blood sugar control and reduce appetite.

In India, Mounjaro is approved by regulators to treat weight loss, or those with metabolic disorders like pre-diabates, PCOS, Type 2 diabetes, Thyroid etc. Mounjaro should be used as part of a comprehensive plan including a healthy diet and exercise to build muscle, stay healthy, and not just lose weight.

Practical Guide: Dosage, Safety & Side Effects

In India, Mounjaro is available at doses of 2.5 mg and 5 mg. It’s given by subcutaneous injection (usually in the abdomen) once weekly on the same day each week, at any time of day, with or without food. To start therapy, doctors prescribe a low dose and gradually escalate to minimize gastrointestinal side effects. Patients should always use a new needle for each injection. Pens should be refrigerated before first use (per manufacturer’s instructions) but may be stored at room temperature for a limited time after opening. Do not change doses or stop treatment without consulting the prescribing physician.

The most common side effects of Mounjaro are gastrointestinal. In studies and real-world use, patients often experience nausea, vomiting, diarrhea, constipation, abdominal (stomach) pain, or bloating, especially when starting the dose (in the first couple weeks). These symptoms tend to be mild-to-moderate and often lessen over time or with slower dose titration. Other side effects may include decreased appetite (which aids weight loss), fatigue, dizziness, headache, and injection-site reactions (redness or itching). Since it affects everyone differently, doctor supervision is key.

Mounjaro is a prescription medicine. It should be used only under the guidance of a qualified doctor. Before starting, tell your doctor about any personal or family history of thyroid cancer, pancreatitis, kidney problems, or diabetic retinopathy, and undertake diagnostic/lab tests for the same. This medication is not for people with Type 1 diabetes or diabetic ketoacidosis. Women who are pregnant or planning pregnancy should discuss risks – GLP-1 agonists are generally not recommended in pregnancy. Breastfeeding mothers should also use caution. Always follow the prescribed dose schedule exactly and maintain regular follow-ups for monitoring (glucose, kidney function, etc.). As with any medication, inform your doctor of all other drugs and supplements you take.

All these medications require a physician’s prescription and supervision. They should only be used under medical guidance as part of a comprehensive treatment plan including diet, exercise, and monitoring. Each drug carries its own precautions. This information is provided for general educational purposes and does not replace professional medical advice. Patients should consult their healthcare provider for personalized guidance and immediately report any concerning symptoms.